Novel pyrazolo[4,3-d]pyrimidine microtubule targeting agents (MTAs): Synthesis, structure–activity relationship, in vitro and in vivo evaluation as antitumor agents
Author:
Funder
NIH
Publisher
Elsevier BV
Subject
Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry
Reference43 articles.
1. https://www.who.int/news-room/fact-sheets/detail/cancer.
2. Microtubule-targeting agents augment the toxicity of DNA-damaging agents by disrupting intracellular trafficking of DNA repair proteins;Poruchynsky;Proc Natl Acad Sci USA,2015
3. Tubulin: structure, functions and roles in disease;Binarova;Cells,2019
4. Revisiting microtubule targeting agents: alpha-Tubulin and the pironetin binding site as unexplored targets for cancer therapeutics;Coulup;Bioorg Med Chem Lett,2019
5. Microtubule-targeting agents are clinically successful due to both mitotic and interphase impairment of microtubule function;Field;Bioorg Med Chem,2014
Cited by 10 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Development of tubulin polymerization inhibitors as anticancer agents;Expert Opinion on Therapeutic Patents;2023-11-02
2. Synthesis and biological evaluation of novel 5‐substituted/unsubstituted triazolothiadiazines as tubulin depolymerizing and vascular disrupting agents with promising antitumor activity;Drug Development Research;2023-04-23
3. Enhancing Oral Performance of Paclitaxel Lipid‐Mimic Prodrug via Modulating Type of Fatty Acids;Advanced Healthcare Materials;2023-03-31
4. Recent Advances in Synthesis and Properties of Pyrazoles;Chemistry;2022-08-29
5. Cancer targeted drug delivery using active low-density lipoprotein nanoparticles encapsulated pyrimidines heterocyclic anticancer agents as microtubule inhibitors;Drug Delivery;2022-08-26
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3