Recent progress in covalent warheads for in vivo targeting of endogenous proteins
Author:
Publisher
Elsevier BV
Subject
Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry
Reference147 articles.
1. The Resurgence of Covalent Drugs;Singh;Nat. Rev. Drug. Discov.,2011
2. Covalent Modifiers: An Orthogonal Approach to Drug Design;Potashman;J. Med. Chem.,2009
3. Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans;Thorarensen;J. Med. Chem.,2019
4. Covalent-Allosteric Inhibitors to Achieve Akt Isoform-Selectivity;Quambusch;Angew. Chem. Int. Ed.,2019
5. BIBW2992, an Irreversible EGFR/HER2 Inhibitor Highly Effective in Preclinical Lung Cancer Models;Li;Oncogene,2008
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