Design, synthesis and evaluation of phthalide alkyl tertiary amine derivatives as promising acetylcholinesterase inhibitors with high potency and selectivity against Alzheimer's disease-Reference-Cited by-同舟云学术

Design, synthesis and evaluation of phthalide alkyl tertiary amine derivatives as promising acetylcholinesterase inhibitors with high potency and selectivity against Alzheimer's disease

Published:2020-04 Issue:8 Volume:28 Page:115400
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Luo Li,Song Qing,Li Yan,Cao Zhongcheng,Qiang Xiaoming,Tan Zhenghuai,Deng Yong

Funder

Sichuan Science and Technology Program

Fundamental Research Funds for the Central Universities

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

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3. Multi-target-directed drug design strategy: from a dual binding site acetylcholinesterase inhibitor to a trifunctional compound against Alzheimer's disease;Bolognesi;J Med Chem,2007

4. Alzheimer's disease;Querfurth;N Engl J Med,2010

5. Pharmacology of selective acetylcholinesterase inhibitors: implications for use in Alzheimer's disease;Liston;Eur J Pharmacol,2004

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