Pharmacological evaluation of novel (6-aminopyridin-3-yl)(4-(pyridin-2-yl)piperazin-1-yl) methanone derivatives as TRPV4 antagonists for the treatment of pain-Reference-Cited by-同舟云学术

Pharmacological evaluation of novel (6-aminopyridin-3-yl)(4-(pyridin-2-yl)piperazin-1-yl) methanone derivatives as TRPV4 antagonists for the treatment of pain

Published:2017-04 Issue:7 Volume:25 Page:2177-2190
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Tsuno Naoki,Yukimasa Akira,Yoshida Osamu,Suzuki Shinji,Nakai Hiromi,Ogawa Tomoyuki,Fujiu Motohiro,Takaya Kenji,Nozu Azusa,Yamaguchi Hiroki,Matsuda Hidetoshi,Funaki Satoko,Yamanada Natsue,Tanimura Miki,Nagamatsu Daiki,Asaki Toshiyuki,Horita Narumi,Yamamoto Miyuki,Hinata Mikie,Soga Masahiko,Imai Masayuki,Morioka Yasuhide,Kanemasa Toshiyuki,Sakaguchi Gaku,Iso Yasuyoshi

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference34 articles.

1. TRPs in Our Senses

2. Transient receptor potential channels as therapeutic targets

3. OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity

4. TRPV4 calcium entry channel: a paradigm for gating diversity

5. The vanilloid transient receptor potential channel TRPV4: From structure to disease

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