Synthesis and cytotoxic activity of lipophilic sulphonamide derivatives of the benzo[ b ]thiophene 1,1-dioxide

Author:

Villar R.,Encio I.,Migliaccio M.,Gil M.J.,Martinez-Merino V.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference13 articles.

1. Martı́nez-Merino, V.; Gil, M. J.; Encı́o, I.; Migliaccio, M.; Arteaga, C. 2000. PCT Patent WO 00/63202.

2. New cytotoxic benzo(b)thiophenilsulfonamide 1,1-dioxide derivatives inhibit a NADH oxidase located in plasma membranes of tumour cells

3. New benzo(b)thiophenesulphonamide 1,1-dioxide derivatives induce a reactive oxygen species-mediated process of apoptosis in tumour cells

4. Novel agents effective against solid tumors: the diarylsulfonylureas. Synthesis, activities, and analysis of quantitative structure-activity relationships

5. Martı́nez-Merino, V.; Martı́nez-González, A.; González, A.; Gil, M. J. In QSAR and Molecular Modelling: Concepts, Computational Tools and Biological Applications. Proceedings of the 10th European Symposium on Structure-Activity Relationships: QSAR and Molecular Modelling, Barcelona 1994. Edited by Prous Science Publishers, Barcelona 1995, 478–80.

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