The complexity of the Nrf2 pathway: beyond the antioxidant response

Author:

Huang Ying,Li Wenji,Su Zheng-yuan,Kong Ah-Ng Tony

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Nutrition and Dietetics,Molecular Biology,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference246 articles.

1. An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements;Itoh;Biochem Biophys Res Commun,1997

2. The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes;McMahon;Cancer Res,2001

3. Nrf2 is essential for the chemopreventive efficacy of oltipraz against urinary bladder carcinogenesis;Iida;Cancer Res,2004

4. Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice;Ramos-Gomez;Proc Natl Acad Sci U S A,2001

5. Targeting NRF2 signaling for cancer chemoprevention;Kwak;Toxicol Appl Pharmacol,2010

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