Quercetin's Neuroprotective Role: Activating Nrf2 Signaling Pathways

Abstract

Abstract: With the global elderly population projected to double by 2050, there is an increasing need to address the risk factors associated with neurodegenerative diseases. This article focuses on exploring the potential neuroprotective effects of quercetin mediated through the Nrf2 signaling pathway. Quercetin, a flavonoid pigment known for its antioxidant properties, can directly interact with Keap1, leading to the dissociation of Nrf2 from the Keap1-Nrf2 complex. Consequently, Nrf2 is released and translocates to the nucleus, initiating the transcription of antioxidant enzymes, such as heme oxygenase-1, NAD(P) H: quinone oxidoreductase 1, and glutathione S-transferase. The exploration of quercetin as an Nrf2 activator holds significant therapeutic implications for neurodegenerative disorders. Human studies demonstrate the efficacy of quercetin in neurodegenerative diseases, while animal studies highlight the protective effects of the Nrf2 signaling pathway. Additionally, Nrf2 regulates proinflammatory cytokines. This study aims to investigate the potential neuroprotective effects of quercetin mediated through the Nrf2 signaling pathway. By targeting oxidative stress, neuroinflammation, and improving mitochondrial function, quercetin shows promise as a candidate for preventing or slowing the progression of neurodegenerative diseases.