Hydrolysis of thalidomide abrogates its ability to enhance mononuclear cell synthesis of IL-2 as well as its ability to suppress the synthesis of TNF-α

Author:

Shannon E.J,Sandoval Felipe,L. Krahenbuhl James

Publisher

Elsevier BV

Subject

Pharmacology

Reference21 articles.

1. Barnhill RL, Doll NJ, Millikan LE, Hastings, RC. Studies on the anti-inflammatory properties of thalidomide: Effects on polymorphonuclear leukocytes and monocytes. J Am Acad Dermatol 1984; 11: 814–819.

2. Faigle JW, Keberle H, Riess W, Schmie K. The metabolic fate of thalidomide. Experientia 1962; 18: 389.

3. Fernandez LP, Schlegel PG, Baker J, Chen Y, Chao NJ. Does thalidomide affect IL-2 response and production? Exp Hematol 1995; 23: 978–985.

4. Green JN, Benson BC. The spectrophotometric determination of thalidomide in body fluids. J Pharmacol 1961; 13: 117–121.

5. Günzler V, Hanauske-Abel HM, Tschank G, Schulte-Wissermann H. Immunological effects of thalidomide. Arzneim-Forsch/Drug Res 1986; 36(11): 1138–1141.

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