Biologically based dose response model for hepatic toxicity: a mechanistically based replacement for traditional estimates of noncancer risk

Author:

Conolly Rory B.,Butterworth Byron E.

Publisher

Elsevier BV

Subject

Toxicology,General Medicine

Reference11 articles.

1. Development of a physiologically-based toxicokinetic model for chloroform;Corley;Toxicol. Appl. Pharmacol.,1990

2. Biochemical toxicology of chloroform;Polh,1979

3. Estimating the risk of liver cancer associated with human exposures to chloroform using physiologically based pharmacokinetic modeling;Reitz;Toxicol. Appl. Pharmacol.,1990

4. Cytolethality of chloroform toward freshly isolated rat and mouse hepatocytes using physiologically realistic exposure conditions;Laethem,1994

5. Induced cytotoxicity and cell proliferation in the hepatocarcinogenicity of chloroform in female B6C3F1 mice: comparison of administration by gavage in corn oil vs. ad libitum in drinking water;Larson;Fundam. Appl. Toxicol.,1994

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