Toxicokinetics as a key to the integrated toxicity risk assessment based primarily on non-animal approaches

Author:

Coecke Sandra,Pelkonen Olavi,Leite Sofia Batista,Bernauer Ulrike,Bessems Jos GM,Bois Frederic Y.,Gundert-Remy Ursula,Loizou George,Testai Emanuela,Zaldívar José-Manuel

Funder

Fundação para a Ciência e Tecnologia Grant

Publisher

Elsevier BV

Subject

Toxicology,General Medicine

Reference66 articles.

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2. Toxicokinetic modeling and its applications in chemical risk assessment;Andersen;Toxicol. Lett.,2003

3. A model for pharmacokinetics and physiological feedback among hormones of the testicular-pituitary axis in adult male rats: a framework for evaluating effects of endocrine active compounds;Barton;Toxicol. Sci.,1998

4. Bessems, J.G.M., 2009. Opinion on the usefulness of in vitro data for human risk assessment. Suggestions for better use of non-testing approaches. Letter report 320016002/2009 RIVM. http://www.rivm.nl/bibliotheek/rapporten/320016002.pdf.

5. Toxicodynamic modelling and the interpretation of in vitro toxicity data;Blaauboer;Toxicol. Lett.,2001

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