Validation of a multiplexed LC–MS/MS clinical assay to quantify insulin-like growth factor-binding proteins in human serum and its application in a clinical study

Author:

Liu Nanjun,Tengstrand Elizabeth,Boernsen K. Olaf,Bek Stephan,Hsieh Frank

Publisher

Elsevier BV

Subject

Pharmacology,Toxicology

Reference32 articles.

1. Method development for absolute quantification of insulin growth factor binding proteins (IGFBP) in plasma samples by capillary LC–MS;Boernsen,2009

2. Investigation of peptide loss in MRM-experiments during absolute protein quantitation. WP 108/#179;Boernsen,2010

3. Functional and total IGFBP3 for the assessment of disorders of the GH/IGF1 axis in children with chronic kidney disease, GH deficiency, or short stature after SGA status at birth;Büscher;Eur. J. Endocrinol.,2012

4. Targeted peptide measurements in biology and medicine: best practices for mass spectrometry-based assay development using a fit-for-purpose approach;Carr;Mol. Cell. Proteomics,2014

5. A randomized, placebo-controlled phase 2 study of ganitumab or conatumumab in combination with FOLFIRI for second-line treatment of mutant KRAS metastatic colorectal cancer;Cohn;Ann. Oncol.,2013

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