A randomized, placebo-controlled phase 2 study of ganitumab or conatumumab in combination with FOLFIRI for second-line treatment of mutant KRAS metastatic colorectal cancer

Author:

Cohn A.L.,Tabernero J.,Maurel J.,Nowara E.,Sastre J.,Chuah B.Y.S.,Kopp M.V.,Sakaeva D.D.,Mitchell E.P.,Dubey S.,Suzuki S.,Hei Y.-J.,Galimi F.,McCaffery I.,Pan Y.,Loberg R.,Cottrell S.,Choo S.-P.

Funder

Amgen Inc

Publisher

Elsevier BV

Subject

Oncology,Hematology

Reference42 articles.

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2. Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer;Van Cutsem;J Clin Oncol,2007

3. Randomized phase III study of panitumumab with fluorouracil, leucovorin, and irinotecan (FOLFIRI) compared with FOLFIRI alone as second-line treatment in patients with metastatic colorectal cancer;Peeters;J Clin Oncol,2010

4. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer;Hurwitz;N Engl J Med,2004

5. Intravenous (IV) aflibercept versus placebo in combination with irinotecan/5-FU (FOLFIRI) for second-line treatment of metastatic colorectal cancer (MCRC): results of a multinational phase III trial (EFC10262-VELOUR);Van Cutsem;Presented at: 13th World Congress on Gastrointestinal Cancer,2011

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