Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels

Author:

Xia Menghang,Shahane Sampada A.,Huang Ruili,Titus Steven A.,Shum Enoch,Zhao Yong,Southall Noel,Zheng Wei,Witt Kristine L.,Tice Raymond R.,Austin Christopher P.

Publisher

Elsevier BV

Subject

Pharmacology,Toxicology

Reference47 articles.

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2. The multitude and diversity of environmental carcinogens;Belpomme;Environ. Res.,2007

3. Reproductive toxicology of 1,3-diphenylguanidine: analysis of induced sperm abnormalities in mice and hamsters and reproductive consequences in mice;Bempong;J. Toxicol. Environ. Health,1983

4. HERG and KvLQT1/IsK, the cardiac K+ channels involved in long QT syndromes, are targets for calcium channel blockers;Chouabe;Mol. Pharmacol.,1998

5. Toward a Pharmacophore for Drugs Inducing the Long QT Syndrome: Insights from a CoMFA Study of HERG K+ Channel Blockers;Cavalli;J. Med. Chem.,2002

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