Downregulation of cytochromes P450 in growth-stimulated rat hepatocytes: role of c-Myc induction and impaired C/EBP binding to DNA

Author:

Tinel Marina,Berson Alain,Elkahwaji Johny,Cresteil Thierry,Beaune Philippe,Pessayre Dominique

Publisher

Elsevier BV

Subject

Hepatology

Reference37 articles.

1. Regulation of cytochrome P-450 CYP1A1 gene expression and protooncogene expression by growth factors in primary hepatocytes;Höhne;FEBS Lett,1990

2. Suppression of constitutive cytochrome P450 gene expression by epidermal growth factor receptor ligands in cultured rat hepatocytes;Ching;Drug Metab Dispos,1996

3. Effect of cell density and epidermal growth factor on the inducible expression of CYP3A and CYP1A genes in human hepatocytes in primary culture;Gruet;Hepatology,1997

4. Epidermal growth factor regulation of female-dependent CYP2A1 and CYP2C12 in primary rat hepatocyte culture;Garcia;Drug Metab Dispos,2001

5. Interleukin-2 overexpresses c-myc and down-regulates cytochrome P-450 in rat hepatocytes;Tinel;J Pharmacol Exp Ther,1999

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