TGFβ1-mediated suppression of cytochrome P450(CYP) induction responses in rat hepatocyte-fibroblast co-cultures

Author:

Yu Yu,Ananthanarayanan Abhishek,Singh Nisha Hari,Hong Xin,Sakban Rashidah Binte,Mittal Nikhil,Xiaobei Luo,Robens Jeffrey,Xia Lei,McMillian Michael,Yu HanryORCID

Funder

Janssen

Institute of Bioengineering and Nanotechnology, A*STAR

SMART BioSyM

NMRC CBRG

Mechanobiology Institute

Publisher

Elsevier BV

Subject

Toxicology,General Medicine

Reference26 articles.

1. Transforming growth factor-beta 1 down-regulates basal and polycyclic aromatic hydrocarbon-induced cytochromes P-450 1A1 and 1A2 in adult human hepatocytes in primary culture;Abdel-Razzak;Mol. Pharmacol.,1994

2. Microfabrication of hepatocyte/fibroblast co-cultures: role of homotypic cell interactions;Bhatia;Biotechnol. Prog.,1998

3. Nuclear receptors PXR and CAR: implications for drug metabolism regulation, pharmacogenomics and beyond;Chai;Expert Opin. Drug Metab. Toxicol.,2013

4. TGF-beta1 regulation in hepatocyte-NIH3T3 co-culture is important for the enhanced hepatocyte function in 3D microenvironment;Chia;Biotechnol. Bioeng.,2005

5. Effects of epidermal growth factor on CYP inducibility by xenobiotics, DNA replication, and caspase activations in collagen I gel sandwich cultures of rat hepatocytes;De Smet;Biochem. Pharmacol.,2001

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