EZH2i EPZ-6438 and HDACi vorinostat synergize with ONC201/TIC10 to activate integrated stress response, DR5, reduce H3K27 methylation, ClpX and promote apoptosis of multiple tumor types including DIPG-Reference-Cited by-同舟云学术

EZH2i EPZ-6438 and HDACi vorinostat synergize with ONC201/TIC10 to activate integrated stress response, DR5, reduce H3K27 methylation, ClpX and promote apoptosis of multiple tumor types including DIPG

Published:2021-08 Issue:8 Volume:23 Page:792-810
ISSN:1476-5586
Container-title:Neoplasia
language:en
Short-container-title:Neoplasia

Author:

Zhang Yiqun,Zhou Lanlan,Safran Howard,Borsuk Robyn,Lulla Rishi,Tapinos Nikos,Seyhan Attila A.,El-Deiry Wafik S.

Publisher

Elsevier BV

Subject

Cancer Research

Reference30 articles.

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2. ONC201 demonstrates antitumor effects in both triple-negative and non-triple-negative breast cancers through TRAIL-dependent and TRAIL-independent mechanisms;Ralff;Mol Cancer Ther,2017

3. The preclinical evaluation of TIC10/ONC201 as an anti-pancreatic cancer agent;Zhang;Biochem Biophys Res Commun,2016

4. ONC201 induces cell death in pediatric non-Hodgkin's lymphoma cells;Talekar;Cell Cycle,2015

5. Single agent and synergistic combinatorial efficacy of first-in-class small molecule imipridone ONC201 in hematological malignancies;Prabhu;Cell Cycle,2018

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