Single agent and synergistic combinatorial efficacy of first-in-class small molecule imipridone ONC201 in hematological malignancies-Reference-Cited by-同舟云学术

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Single agent and synergistic combinatorial efficacy of first-in-class small molecule imipridone ONC201 in hematological malignancies

Published:2018-02-16 Issue:4 Volume:17 Page:468-478
ISSN:1538-4101
Container-title:Cell Cycle
language:en
Short-container-title:Cell Cycle

Author:

Prabhu Varun V.¹,Talekar Mala K.²,Lulla Amriti R.³^ORCID,Kline C. Leah B.³,Zhou Lanlan³^ORCID,Hall Junior²,Van den Heuvel A. Pieter J.⁴,Dicker David T.³,Babar Jawad³^ORCID,Grupp Stephan A.²,Garnett Mathew J.⁵,McDermott Ultan⁵,Benes Cyril H.⁶,Pu Jeffrey J.⁴,Claxton David F.⁴,Khan Nadia³^ORCID,Oster Wolfgang¹,Allen Joshua E.¹,El-Deiry Wafik S.¹

Affiliation:

1. Oncoceutics, Inc., Philadelphia, PA

2. The Children's Hospital of Philadelphia, Philadelphia, PA

3. Fox Chase Cancer Center, Philadelphia, PA

4. Penn State College of Medicine, Hershey, PA

5. Wellcome Trust Sanger Institute, Hinxton, UK

6. Massachusetts General Hospital, Harvard Medical School, Boston, MA

Funder

NIH

Publisher

Informa UK Limited

Subject

Cell Biology,Developmental Biology,Molecular Biology

Link

https://www.tandfonline.com/doi/pdf/10.1080/15384101.2017.1403689

Reference35 articles.

1. Discovery and clinical introduction of first-in-class imipridone ONC201

2. Dual Inactivation of Akt and ERK by TIC10 Signals Foxo3a Nuclear Translocation, TRAIL Gene Induction, and Potent Antitumor Effects

3. ONC201 kills solid tumor cells by triggering an integrated stress response dependent on ATF4 activation by specific eIF2α kinases

4. ATF4 induction through an atypical integrated stress response to ONC201 triggers p53-independent apoptosis in hematological malignancies

5. Small-Molecule ONC201/TIC10 Targets Chemotherapy-Resistant Colorectal Cancer Stem–like Cells in an Akt/Foxo3a/TRAIL–Dependent Manner

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3. Syrosingopine and UK5099 synergistically suppress non-small cell lung cancer by activating the integrated stress response;Cell Death & Disease;2024-06-19

4. The oncolytic adenovirus Delta-24-RGD in combination with ONC201 induces a potent antitumor response in pediatric high-grade and diffuse midline glioma models;Neuro-Oncology;2024-03-30

5. The Imipridone ONC213 Targets α-Ketoglutarate Dehydrogenase to Induce Mitochondrial Stress and Suppress Oxidative Phosphorylation in Acute Myeloid Leukemia;Cancer Research;2024-01-24

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