The Effects of Intradermal and Topical Mitomycin C on Wound Healing-Reference-Cited by-同舟云学术

The Effects of Intradermal and Topical Mitomycin C on Wound Healing

Published:2006-07 Issue:1 Volume:135 Page:56-60
ISSN:0194-5998
Container-title:Otolaryngology–Head and Neck Surgery
language:en
Short-container-title:Otolaryngol Head Neck Surg

Author:

Porter Glen T.¹²,Gadre Swarupa A.¹³,Calhoun Karen H.¹⁴

Affiliation:

1. Nellis Air Force Base, Nevada; Houston, Texas; and Columbia, Missouri

2. Mike O'Callaghan Federal Hospital;

3. Nellis AFB; the Anderson Cancer Center, Houston, TX;

4. University of Missouri-Columbia

Abstract

OBJECTIVE: To determine the effect of intradermal and topical mitomycin C (MMC) on skin wound healing. STUDY DESIGN/SETTING: A prospective, controlled study in a rat wound model performed in an academic medical center. RESULTS: Intradermal and topical MMC application decreased wound integrity when compared with saline-treated animals at 1 week, 2 weeks, 1 month, and 6 months. Skin necrosis occurred in animals that received intradermal MMC. Hemotoxylin and eosin and immunohistochemical staining showed no consistent difference between treatment arms. Fibrosis and collagen deposition were reduced in MMC-treated wounds on trichrome staining. CONCLUSIONS: MMC-treated wounds showed decreased wound strength compared with controls. Intradermal MMC can cause skin necrosis. Histologic findings did not always correspond with clinical data. SIGNIFICANCE: The data suggest cautious use of MMC in clinical situations when wound breaking strength is critical.

Publisher

SAGE Publications

Subject

Otorhinolaryngology,Surgery

Link

http://journals.sagepub.com/doi/pdf/10.1016/j.otohns.2006.02.024

Reference14 articles.

1. Topical Mitomycin as an Adjunct to Choanal Atresia Repair

2. Safety and Efficacy of Topical Mitomycin C in Myringotomy Patency

3. Effect of Mitomycin C on Keloid Fibroblasts: An In Vitro Study

4. Sinus Surgery: Does Mitomycin C Reduce Stenosis?

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