Affiliation:
1. College of Chemistry and Chemical Engineering Inner Mongolia University Inner Mongolia 010020 China
2. Beijing National Laboratory for Molecular Sciences Centre for Soft Matter Science and Engineering Key Lab of Polymer Chemistry and Physics of the Ministry of Education College of Chemistry Peking University Beijing 100871 China
3. Beijing National Laboratory for Molecular Sciences Key Laboratory of Molecular Nanostructure and Nanotechnology Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China
Abstract
AbstractThe effective treatment of chronic wounds represents a critical global medical challenge demanding urgent attention. Persistent inflammation, driven by an excess of reactive oxygen radicals, sets in motion a detrimental cycle leading to chronic wounds and impeding the natural healing process. This study develops a sprayable wound dressing by covalently grafting amino fullerene to carboxymethylated curdlan (CMC‐C). This novel dressing exhibits excellent biocompatibility, antioxidant, and reactive oxygen species scavenging properties. Furthermore, it demonstrates a targeted affinity for HEK‐a cells, efficiently reducing the inflammatory response while promoting cell proliferation and migration in vitro. Moreover, the animal experiment investigations reveal that CMC‐C significantly accelerates chronic wounds healing by regulating the inflammatory process, promoting collagen deposition, and improving vascularization. These results demonstrate the potential of the sprayable dressing (CMC‐C) in curing the healing of chronic wounds through the modulation of the inflammatory microenvironment. Overall, the sprayable hydrogel dressing based on water‐soluble derivative of fullerene and curdlan emerges as a potential approach for clinical applications in the treatment of chronic wounds.
Funder
National Natural Science Foundation of China