Tolerability of lacosamide rapid dose titration: A randomized, multicenter, prospective, open-label study

Author:

Shin Yong-Won,Moon Jangsup,Cho Yong Won,Kim Dong Wook,Hong Sang Bin,Kim Do-Yong,Chang Hyeyeon,Yoon Seo Hyun,Yu Kyung-Sang,Jang In-Jin,Lee Soon-Tae,Jung Keun-Hwa,Park Kyung-Il,Jung Ki-Young,Kim Manho,Chu Kon,Lee SeungHwan,Lee Sang Kun

Funder

SK chemicals

Publisher

Elsevier BV

Subject

Behavioral Neuroscience,Neurology (clinical),Neurology

Reference11 articles.

1. The investigational anticonvulsant lacosamide selectively enhances slow inactivation of voltage-gated sodium channels;Errington;Mol Pharmacol,2008

2. Tolerability, pharmacokinetics, and bioequivalence of the tablet and syrup formulations of lacosamide in plasma, saliva, and urine: saliva as a surrogate of pharmacokinetics in the central compartment;Cawello;Epilepsia,2013

3. Comparison of lacosamide concentrations in cerebrospinal fluid and serum in patients with epilepsy;May;Epilepsia,2015

4. Acute or chronic use of lacosamide does not alter its distribution between serum and cerebrospinal fluid;Michelhaugh;Epilepsia,2015

5. U.S. Food and Drug Administration. Vimpat ® (lacosamide): highlights of prescribing information. Available at: https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/022255s026s027,022254s019s020,022255s012s013lbl.pdf. Accessed July 30, 2020.

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