Comparison of lacosamide concentrations in cerebrospinal fluid and serum in patients with epilepsy

Author:

May Theodor W.1,Brandt Christian2,Helmer Renate1,Bien Christian G.2,Cawello Willi3

Affiliation:

1. Society for Epilepsy Research; Bielefeld Germany

2. Epilepsy Center Bethel; Bielefeld Germany

3. UCB Pharma; Monheim am Rhein Germany

Publisher

Wiley

Subject

Clinical Neurology,Neurology

Reference13 articles.

1. UCB Pharma Vimpat ® (lacosamide tablets, injection, oral solution) [U.S. prescribing information] Smyrna UCB, Inc http://www.vimpat.com/pdf/vimpat_PI.pdf

2. UCB Pharma Vimpat ® (lacosamide) EMA summary of product characteristics http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/000863/WC500050338.pdf

3. Lacosamide: a review of preclinical properties;Beyreuther;CNS Drug Rev,2007

4. Tolerability, pharmacokinetics, and bioequivalence of the tablet and syrup formulations of lacosamide in plasma, saliva, and urine: saliva as a surrogate of pharmacokinetics in the central compartment;Cawello;Epilepsia,2013

5. Absorption, disposition, metabolic fate and elimination of the anti-epileptic drug lacosamide in humans: mass balance following intravenous and oral administration;Cawello;Eur J Drug Metab Pharmacokinet,2012

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