Janus kinase 2 activation mechanisms revealed by analysis of suppressing mutations

Author:

Hammarén Henrik M.,Virtanen Anniina T.,Abraham Bobin George,Peussa Heidi,Hubbard Stevan R.,Silvennoinen Olli

Funder

Academy of Finland

Sigrid Jusélius Foundation

Jane and Aatos Erkko Foundation

Finnish Cancer Foundation

Prostate Cancer Foundation

Tampere Tuberculosis Foundation

Tampere University Hospital

National Institutes of Health

Pfizer

Publisher

Elsevier BV

Subject

Immunology,Immunology and Allergy

Reference52 articles.

1. The Janus kinases (Jaks);Yamaoka;Genome Biol,2004

2. Type I/II cytokines, JAKs, and new strategies for treating autoimmune diseases;Schwartz;Nat Rev Rheumatol,2016

3. The regulation of JAKs in cytokine signaling and its breakdown in disease;Hammarén;Cytokine,2018

4. JAK inhibition as a therapeutic strategy for immune and inflammatory diseases;Schwartz;Nat Rev Drug Discov,2017

5. The Janus kinase (JAK) FERM and SH2 domains: bringing specificity to JAK–receptor interactions;Ferrao;Front Endocrinol,2017

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