JAK inhibitor selectivity: new opportunities, better drugs?

Author:

Virtanen Anniina,Spinelli Francesca Romana,Telliez Jean Baptiste,O’Shea John J.,Silvennoinen Olli,Gadina MassimoORCID

Publisher

Springer Science and Business Media LLC

Reference185 articles.

1. Russell, S. M. et al. Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development. Science 270, 797–800 (1995).

2. Firmbach-Kraft, I., Byers, M., Shows, T., Dalla-Favera, R. & Krolewski J. J. tyk2, prototype of a novel class of non-receptor tyrosine kinase genes. Oncogene 5, 1329–1336 (1990).

3. Wilks, A. F. et al. Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase. Mol. Cell Biol. 11, 2057–2065 (1991).

4. Silvennoinen, O. et al. Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction. Proc. Natl Acad. Sci. USA 90, 8429–8433 (1993).

5. Johnston, J. A. et al. Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2. Nature 370, 151–153 (1994).

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