Dampening of the bone formation response following repeat dosing with sclerostin antibody in mice is associated with up-regulation of Wnt antagonists
Author:
Funder
UCB
Publisher
Elsevier BV
Subject
Histology,Physiology,Endocrinology, Diabetes and Metabolism
Reference42 articles.
1. Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST);Balemans;Hum. Mol. Genet.,2001
2. Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein;Brunkow;Am. J. Hum. Genet.,2001
3. Characterization of the interaction of sclerostin with the low density lipoprotein receptor-related protein (LRP) family of Wnt co-receptors;Holdsworth;J. Biol. Chem.,2012
4. Binds to LRP5/6 and antagonizes canonical Wnt signaling;Li;J. Biol. Chem.,2005
5. SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor;Semenov;J. Biol. Chem.,2005
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1. Inhibition of both sclerostin and DKK1 results in novel skull findings in the rat and non-human primate that is not observed with inhibition of sclerostin alone;Bone;2024-02
2. Τhe story of sclerostin inhibition: the past, the present, and the future;Hormones;2024-01-03
3. Sclerostin blockade inhibits bone resorption through PDGF receptor signaling in osteoblast lineage cells;2023-09-15
4. Research progress on the role of lncRNA–miRNA networks in regulating adipogenic and osteogenic differentiation of bone marrow mesenchymal stem cells in osteoporosis;Frontiers in Endocrinology;2023-08-14
5. Dual Inhibition of the Wnt Inhibitors DKK1 and Sclerostin Promotes Fracture Healing and Increases the Density and Strength of Uninjured Bone;Journal of Bone and Joint Surgery;2023-05-09
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