Melflufen or pomalidomide plus dexamethasone for patients with multiple myeloma refractory to lenalidomide (OCEAN): a randomised, head-to-head, open-label, phase 3 study

Author:

Schjesvold Fredrik H,Dimopoulos Meletios-Athanasios,Delimpasi Sosana,Robak Pawel,Coriu Daniel,Legiec Wojciech,Pour Luděk,Špička Ivan,Masszi Tamas,Doronin Vadim,Minarik Jiri,Salogub Galina,Alekseeva Yulia,Lazzaro Antonio,Maisnar Vladimir,Mikala Gábor,Rosiñol Laura,Liberati Anna Marina,Symeonidis Argiris,Moody Victoria,Thuresson Marcus,Byrne Catriona,Harmenberg Johan,Bakker Nicolaas A,Hájek Roman,Mateos Maria-Victoria,Richardson Paul G,Sonneveld Pieter,Schjesvold Fredrik,Delimpasi Sosana,Robak Pawel,Coriu Daniel,Nikolayeva Anna,Tomczak Waldemar,Pour Ludek,Spicka Ivan,Dimopoulos Meletios-Athanasios,Masszi Tamas,Doronin Vadim,Minarik Jiri,Salogub Galina,Alekseeva Yulia,Maisnar Vladimir,Mikala Gabor,Rosinol Laura,Konstantinova Tatiana,Lazzaro Antonio,Liberati Anna Marina,Symeonidis Anargyros,Gatt Moshe,Illes Arpad,Abdulhaq Haifaa,Dungarwalla Moez,Grosicki Sebastian,Hajek Roman,Leleu Xavier,Myasnikov Alexander,Richardson Paul G.,Avivi Irit,Deeren Dries,Gironella Mercedes,Hernandez-Garcia Miguel Teodoro,Martinez Lopez Joaquin,Newinger-Porte Muriel,Ribas Paz,Samoilova Olga,Voog Eric,Arnao-Herraiz Mario,Carrillo-Cruz Estrella,Corradini Paolo,Dodlapati Jyothi,Granell Gorrochategui Miquel,Huang Shang-Yi,Jenner Matthew,Karlin Lionel,Kim Jin Seok,Kopacz Agnieszka,Medvedeva Nadezhda,Min Chang-Ki,Mina Roberto,Palk Katrin,Shin Ho-Jin,Sohn Sang Kyun,Sonneveld Pieter,Tache Jason,Anagnostopoulos Achilles,Arguiñano Jose-Maria,Cavo Michele,Filicko Joanne,Garnes Margaret,Halka Janusz,Herzog-Tzarfati Kathrin,Ipatova Natalia,Kim Kihyun,Krauth Maria-Theresa,Kryuchkova Irina,Lazaroiu Mihaela Cornelia,Luppi Mario,Proydakov Andrei,Rambaldi Alessandro,Rudzianskiene Milda,Yeh Su-Peng,Alcalá-Peña Maria Magdalena,Alegre Amor Adrian,Alizadeh Hussain,Bendandi Maurizio,Brearton Gillian,Brown Randall,Cavet Jim,Dally Najib,Egyed Miklos,Hernández-Rivas José Ángel,Kaare Ain,Karsenti Jean-Michel,Kloczko Janusz,Kreisle William,Lee Je-Jung,Legiec Wojciech,Machherndl-Spandl Sigrid,Manda Sudhir,Mateos Maria-Victoria,Moiseev Ivan,Moreb Jan,Nagy Zsolt,Nair Santosh,Oriol-Rocafiguera Albert,Osswald Michael,Otero-Rodriguez Paula,Peceliunas Valdas,Plesner Torben,Rey Philippe,Rossi Giuseppe,Stevens Don,Suriu Celia,Tarella Corrado,Verlinden Anke,Zannetti Alain

Publisher

Elsevier BV

Subject

Hematology

Reference21 articles.

1. Management of relapsed and refractory multiple myeloma: novel agents, antibodies, immunotherapies and beyond;Chim;Leukemia,2018

2. Outcomes of patients with multiple myeloma refractory to CD38-targeted monoclonal antibody therapy;Gandhi;Leukemia,2019

3. The alkylating prodrug J1 can be activated by aminopeptidase N, leading to a possible target directed release of melphalan;Wickström;Biochem Pharmacol,2010

4. Chauhan D, Ray A, Viktorsson K, et al. Anti-myeloma activity of a novel alkylating agent melphalan-flufenamide. The 18th Congress of the European Hematology Association; June 13–16, 2013: Stockholm: P204 (poster).

5. Melflufen - a peptidase-potentiated alkylating agent in clinical trials;Wickström;Oncotarget,2017

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