The alkylating prodrug J1 can be activated by aminopeptidase N, leading to a possible target directed release of melphalan-Reference-Cited by-同舟云学术

The alkylating prodrug J1 can be activated by aminopeptidase N, leading to a possible target directed release of melphalan

Published:2010-05 Issue:9 Volume:79 Page:1281-1290
ISSN:0006-2952
Container-title:Biochemical Pharmacology
language:en
Short-container-title:Biochemical Pharmacology

Author:

Wickström Malin,Viktorsson Kristina,Lundholm Lovisa,Aesoy Reidun,Nygren Helen,Sooman Linda,Fryknäs Mårten,Vogel Lotte Katrine,Lewensohn Rolf,Larsson Rolf,Gullbo Joachim

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference45 articles.

1. Antitumor activity of the alkylating oligopeptides J1 (l-melphalanyl-p-l-fluorophenylalanine ethyl ester) and P2 (l-prolyl-m-l-sarcolysyl-p-l-fluorophenylalanine ethyl ester): comparison with melphalan;Gullbo;Anticancer Drugs,2003

2. Antitumor efficacy and acute toxicity of the novel dipeptide melphalanyl-p-l-fluorophenylalanine ethyl ester (J1) in vivo;Gullbo;Invest New Drugs,2004

3. Structure–activity relationship for alkylating dipeptide nitrogen mustard derivatives;Gullbo;Oncol Res,2003

4. Activity of hydrolytic enzymes in tumour cells is a determinant for anti-tumour efficacy of the melphalan containing prodrug J1;Gullbo;J Drug Target,2003

5. The novel alkylating prodrug J1: diagnosis directed activity profile ex vivo and combination analyses in vitro;Wickstrom;Invest New Drugs,2008

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