Interaction with 2,4-dinitrophenol correlates with polyreactivity, self-binding, and stability of clinical-stage therapeutic antibodies
Author:
Funder
Fondation ARC pour la Recherche sur le Cancer
Institut National de la Santé et de la Recherche Médicale
Publisher
Elsevier BV
Subject
Molecular Biology,Immunology
Reference34 articles.
1. Establishing in vitro in vivo correlations to screen monoclonal antibodies for physicochemical properties related to favorable human pharmacokinetics;Avery;mAbs,2018
2. IgG auto- and polyreactivities of normal human sera;Berneman;Mol. Immunol.,1993
3. Polyreactive autoantibodies purified from human intravenous immunoglobulins prevent the development of experimental autoimmune diseases;Bruley-Rosset;Lab. Invest.,2003
4. Balancing charge in the complementarity-determining regions of humanized mAbs without affecting pI reduces non-specific binding and improves the pharmacokinetics;Datta-Mannan;mAbs,2015
5. Antibody polyreactivity in health and disease: statu variabilis;Dimitrov;J. Immunol.,2013
Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. DOTAD: A Database of Therapeutic Antibody Developability;Interdisciplinary Sciences: Computational Life Sciences;2024-03-26
2. Identifying developability risks for clinical progression of antibodies using high-throughput in vitro and in silico approaches;mAbs;2023-04-18
3. Non-specificity as the sticky problem in therapeutic antibody development;Nature Reviews Chemistry;2022-11-14
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3