Modeling of the human interleukin 12:receptor complex allows to engineer attenuated cytokine variants

Author:

Liebl Korbinian,Aschenbrenner Isabel,Schiller Lisa,Kerle Anna,Protzer Ulrike,Feige Matthias J.

Funder

Bayerische Forschungsstiftung

Studienstiftung des Deutschen Volkes

Deutsche Forschungsgemeinschaft

Publisher

Elsevier BV

Subject

Molecular Biology,Immunology

Reference24 articles.

1. Structural activation of pro-inflammatory human cytokine IL-23 by cognate IL-23 receptor enables recruitment of the shared receptor IL-12Rβ1;Bloch;Immunity,2018

2. Bloch, Y., Felix, J., Merceron, R., Provost, M., Symakani, R.A., Backer, R.D., Lambert, E., Savvides, S.N., 2023. Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23. bioRxiv, 2023.2003.2013.532366.

3. Interleukins in cancer: from biology to therapy;Briukhovetska;Nat. Rev. Cancer,2021

4. Case, D.A., Babin, V., Berryman, J.T., Betz, R.M., Cai, Q., Cerutti, D.S., Cheatham, T.E. III, Darden, T.A., Duke, R.E., Gohlke, H., Goetz, A.W., Gusarov, S., Homeyer, N., Janowski, P., Kaus, J., Kolossváry, I., Kovalenko, A., Lee, T.S., LeGrand, S., Lucko, T., Luo, R., Madej, B., Merz, K.M., Paesani, F., Roe, D.R., Roitberg, A., Sagui, C., Salomon-Ferrer, R., Seabra, G., Simmerling, C.L., Smith, W., Swails, J., Walker, R.C., Wang, J., Wolf, R.M., Wu, X., Kollmann, P.A., 2014. AMBER 14.

5. Novel strategies exploiting interleukin-12 in cancer immunotherapy;Cirella;Pharmacol. Ther.,2022

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