Improved antigen binding by a CD20-specific single-chain antibody fragment with a mutation in CDRH1

Author:

Adamson P.J.,Millard D.J.,Hohmann A.W.,Mavrangelos C.,Macardle P.J.,Pilkington G.,Mulhern T.D.,Tedder T.F.,Zola H.,Nicholson I.C.

Publisher

Elsevier BV

Subject

Molecular Biology,Immunology

Reference41 articles.

1. Antibody against CD20 in patients with B cell malignancy;Adamson;Leuk. Res.,2001

2. Anderson, D.R., Hanna, N., Leonard, J.E., Newman, R.A., Reff, M.E., Rastetter, W.H., 1998. Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma. USPTO Patent 5,843,439.

3. The Protein Data Bank;Berman;Nucleic Acids Res.,2000

4. Selection for a periplasmic factor improving phage display and functional periplasmic expression;Bothmann;Nat. Biotechnol.,1998

5. Transfection of the CD20 cell surface molecule into ectopic cell types generates a Ca2+ conductance found constitutively in B lymphocytes;Bubien;J. Cell Biol.,1993

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