Mechanistic insights on clearance and inhibition discordance between liver microsomes and hepatocytes when clearance in liver microsomes is higher than in hepatocytes-Reference-Cited by-同舟云学术

Mechanistic insights on clearance and inhibition discordance between liver microsomes and hepatocytes when clearance in liver microsomes is higher than in hepatocytes

Published:2020-12 Issue: Volume:155 Page:105541
ISSN:0928-0987
Container-title:European Journal of Pharmaceutical Sciences
language:en
Short-container-title:European Journal of Pharmaceutical Sciences

Author:

Keefer Christopher,Chang George,Carlo Anthony,Novak Jonathan J.,Banker Michael,Carey Jackie,Cianfrogna Julie,Eng Heather,Jagla Caitlin,Johnson Nathaniel,Jones Rhys,Jordan Samantha,Lazzaro Sarah,Liu JianHua,Scott Obach R.,Riccardi Keith,Tess David,Umland John,Racich Jillian,Varma Manthena,Visswanathan Ravi,Di Li

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference26 articles.

1. https://www.graphpad.com/.

2. Localization of P-gp (Abcb1) and Mrp2 (Abcc2) in freshly isolated rat hepatocytes;Bow;Drug Metab. Dispos.,2008

3. The role of drug metabolizing enzymes in clearance;Di;Expert Opin. Drug Metab. Toxicol.,2014

4. The Critical Role of Passive Permeability in Designing Successful Drugs;Di;ChemMedChem.,2020

5. Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design;Di;Eur. J. Med. Chem.,2012

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