The Critical Role of Passive Permeability in Designing Successful Drugs-Reference-Cited by-同舟云学术

The Critical Role of Passive Permeability in Designing Successful Drugs

Published:2020-09-10 Issue:20 Volume:15 Page:1862-1874
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Di Li¹^ORCID,Artursson Per²^ORCID,Avdeef Alex³^ORCID,Benet Leslie Z.⁴^ORCID,Houston J. Brian⁵^ORCID,Kansy Manfred⁶^ORCID,Kerns Edward H.⁷,Lennernäs Hans²^ORCID,Smith Dennis A.⁸,Sugano Kiyohiko⁹^ORCID

Affiliation:

1. Pharmacokinetics, Dynamics and Metabolism Pfizer Worldwide Research and Development 445 Eastern Point Road Groton CT 06340 USA

2. Department of Pharmacy Uppsala University 752 36 Uppsala Sweden

3. in-ADME Research 1732 First Avenue, #102 New York NY 10128 USA

4. Department of Bioengineering and Therapeutic Sciences UCSF San Francisco CA 94143 USA

5. Division of Pharmacy & Optometry Stopford Building, Oxford Road Manchester M13 9PT UK

6. Retired Germany

7. Retired USA

8. Retired UK

9. College of Pharmaceutical Sciences Department of Pharmacy Ritsumeikan University Noji-higashi, Kusatsu Shiga 525-8577 Japan

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.202000419

Reference141 articles.

1. L. Di E. H. Kerns Drug-Like Properties: Concepts Structure Design and Methods Elevier London UK 2016.

2. Coexistence of passive and carrier-mediated processes in drug transport

3. Jejunal permeability in humans in vivo and rats in situ : investigation of molecular size selectivity and solvent drag

4. Intracellular and Intraorgan Concentrations of Small Molecule Drugs: Theory, Uncertainties in Infectious Diseases and Oncology, and Promise

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