Mechanistic prediction of first-in-human dose for bispecific CD3/EpCAM T-cell engager antibody M701, using an integrated PK/PD modeling method
Author:
Funder
National Natural Science Foundation of China
Publisher
Elsevier BV
Subject
Pharmaceutical Science
Reference30 articles.
1. Use of pharmacokinetic/ pharmacodynamic modelling for starting dose selection in first-in-human trials of high-risk biologics;Agoram;Br. J. Clin. Pharmacol.,2009
2. Effective relief of malignant ascites in patients with advanced ovarian cancer by a trifunctional anti-EpCAM x anti-CD3 antibody: a phase I/II study;Burges;Clin. Cancer Res.,2007
3. Integrated Pharmacokinetic/Pharmacodynamic Model of a Bispecific CD3xCD123 DART Molecule in Nonhuman Primates: evaluation of Activity and Impact of Immunogenicity;Campagne;Clin. Cancer Res.,2018
4. Mechanistic Projection of First-in-Human Dose for Bispecific Immunomodulatory P-Cadherin LP-DART: an Integrated PK/PD Modeling Approach;Chen;Clin. Pharmacol. Ther.,2016
5. Safety issues specific to clinical development of protein therapeutics;Haller;Clin. Pharmacol. Ther.,2008
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