The absorptive flux of the anti-epileptic drug substance vigabatrin is carrier-mediated across Caco-2 cell monolayers

Author:

Nøhr Martha Kampp,Hansen Steen Honoré,Brodin Birger,Holm René,Nielsen Carsten Uhd

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference34 articles.

1. Vigabatrin transport across the human intestinal epithelial (Caco-2) brush-border membrane is via the H+ -coupled amino-acid transporter hPAT1;Abbot;Br. J. Pharmacol.,2006

2. Amino acid transport across mammalian intestinal and renal epithelia;Broer;Physiol. Rev.,2008

3. Center for Drug Evaluation and Research (CDER). Guidance for Industry. Drug Interaction Studies – Study Design, Data Analysis, Implications for Dosing, and Labeling Recommendations. Draft Guidance. US Food and Drug Administration. Updated: Feb. 2012; (accessed 02.13)

4. Structure, function and immunolocalization of a proton-coupled amino acid transporter (hPAT1) in the human intestinal cell line Caco-2;Chen;J. Physiol.,2003

5. Committee for Human Medical Products (CHMP). Guideline on the Investigation of Drug Interactions. European Medicines Agency. Updated: June 2012. (accessed 02.13)

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