Clearance-dependent underprediction of in vivo intrinsic clearance from human hepatocytes: Comparison with permeabilities from artificial membrane (PAMPA) assay, in silico and caco-2 assay, for 65 drugs-Reference-Cited by-同舟云学术

Clearance-dependent underprediction of in vivo intrinsic clearance from human hepatocytes: Comparison with permeabilities from artificial membrane (PAMPA) assay, in silico and caco-2 assay, for 65 drugs

Published:2012-04 Issue:5 Volume:45 Page:570-574
ISSN:0928-0987
Container-title:European Journal of Pharmaceutical Sciences
language:en
Short-container-title:European Journal of Pharmaceutical Sciences

Author:

Hallifax David,Turlizzi Elisa,Zanelli Ugo,Houston J. Brian

Publisher

Elsevier BV

Subject

Pharmaceutical Science

Reference17 articles.

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2. Kinetic determinants of hepatic clearance: plasma protein binding and hepatic uptake;Baker;Xenobiotica,2007

3. In vitro screening models to assess intestinal absorption and metabolism;Deferme,2008

4. Presentation of a modified dispersion model (MDM) for hepatic drug extraction and new methodology for the prediction of the rate limiting step in hepatic metabolic clearance;Fagerholm;Xenobiotica,2009

5. Comparison of intrinsic clearances in human liver microsomes and suspended hepatocytes from the same donor livers: clearance-dependent relationship and implications for prediction of in vivo clearance;Foster;Xenobiotica,2011

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