CAR T-cells: A John von Neumann legacy?

Author:

Quesnel Bruno

Funder

Institut pour la Recherche sur le Cancer de Lille (IRCL)

Publisher

Elsevier BV

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference5 articles.

1. Theory of self-reproducing automata;Neumann,1966

2. Primary results from a randomized (1:1), open-label phase II study of talimogene laherparepvec (T) and ipilimumab (I) vs I alone in unresected stage IIIB-IV melanoma;Chesney;J Clin Oncol,2017

3. Chimeric antigen-receptor T-cell therapy for hematological malignancies and solid tumors: clinical data to date, current limitations and perspectives;Gauthier;Curr Res Transl Med,2017

4. TCR engagement negatively affects CD8 but not CD4 CAR T cell expansion and leukemic clearance;Yang;Sci Transl Med,2017

5. In a model of tumor dormancy, long-term persistent leukemic cells have increased B7-H1 and B7.1 expression and resist CTL-mediated lysis;Saudemont;Blood,2004

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