Discovery of a new mexiletine-derived agonist of the hERG K + channel-Reference-Cited by-同舟云学术

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Discovery of a new mexiletine-derived agonist of the hERG K + channel

Published:2017-10 Issue: Volume:229 Page:62-67
ISSN:0301-4622
Container-title:Biophysical Chemistry
language:en
Short-container-title:Biophysical Chemistry

Author:

Gualdani Roberta,Cavalluzzi Maria Maddalena,Tadini-Buoninsegni Francesco,Lentini Giovanni

Funder

Ente Cassa di Risparmio di Firenze

Publisher

Elsevier BV

Subject

Organic Chemistry,Biochemistry,Biophysics

Reference32 articles.

1. International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels;Gutman;Pharmacol. Rev.,2003

2. hERG K+ channels: Structure, function and clinical significance;Vandenberg;Physiol. Rev.,2012

3. The hERG potassium channel and hERG screening for drug-induced torsades de pointes;Hancox;Pharmacol. Ther.,2008

4. hERG potassium channels and cardiac arrhythmia;Sanguinetti;Nature,2006

5. hERG potassium channels and the structural basis of drug-induced arrhythmias;Mitcheson;Chem. Res. Toxicol.,2008

Cited by 10 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Therapeutic Targeting of Potassium Channels;Ion Channels as Targets in Drug Discovery;2024

2. hERG agonists pose challenges to web-based machine learning methods for prediction of drug-hERG channel interaction;Journal of Pharmacological and Toxicological Methods;2023-09

3. hERG stereoselective modulation by mexiletine‐derived ureas: Molecular docking study, synthesis, and biological evaluation;Archiv der Pharmazie;2023-07-17

4. Pharmacological activation of the hERG K ⁺ channel for the management of the long QT syndrome: A review;Journal of Arrhythmia;2022-06-14

5. Computational and experimental studies on the inhibitory mechanism of hydroxychloroquine on hERG;Toxicology;2021-06

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