Evaluation of novel Akt1 inhibitors as anticancer agents using virtual co-crystallized pharmacophore generation

Author:

Al-Sha’er Mahmoud A.,Mansi Iman,Almazari Inas,Hakooz Nancy

Funder

deanship of Scientific Research at the Zarqa University

deanship of scientific research at the Hashemite University

Publisher

Elsevier BV

Subject

Materials Chemistry,Computer Graphics and Computer-Aided Design,Physical and Theoretical Chemistry,Spectroscopy

Reference35 articles.

1. Activation of AKT kinases in cancer: implications for therapeutic targeting;Bellacosa;Adv. Cancer Res.,2005

2. Targeting serine/threonine protein kinase B/Akt and cell-cycle checkpoint kinases for treating cancer;Li;Curr. Top. Med. Chem.,2002

3. Adenoviral-mediated expression of a kinase-dead mutant of Akt induces apoptosis selectively in tumor cells and suppresses tumor growth in mice;Jetzt;Cancer Res.,2003

4. The biology and clinical relevance of the PTEN tumor suppressor pathway;Sansal;J. Clin. Oncol.,2004

5. Role of the AKT kinase in expansion of multiple myeloma clones: effects on cytokine-dependent proliferative and survival responses;Hsu;Oncogene,2002

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