Towards integrated ADME prediction: past, present and future directions for modelling metabolism by UDP-glucuronosyltransferases

Author:

Smith P.A,Sorich M.J,Low L.S.C,McKinnon R.A,Miners J.O

Publisher

Elsevier BV

Subject

Materials Chemistry,Computer Graphics and Computer-Aided Design,Physical and Theoretical Chemistry,Spectroscopy

Reference62 articles.

1. ADMET in silico modelling: towards prediction paradise?;Van de Waterbeemd;Nat. Rev. Drug Discov.,2003

2. In vitro approaches for the prediction of human drug metabolism;Miners;Ann. Rep. Med. Chem.,1994

3. Integrated cytochrome P450 reaction phenotyping. Attempting to bridge the gap between cDNA-expressed cytochromes P450 and native human liver microsomes;Rodrigues;Biochem. Pharmacol.,1999

4. Hitchhiking the technology bandwagon: the evolution of drug metabolism;Miners;Clin. Exp. Pharmacol. Physiol.,2002

5. Structural and functional studies of UDP-glucuronosyltransferases;Radominska-Pandya;Drug Metab. Rev.,1999

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