A Diarylpentanoid with Potential Activation of the p53 Pathway: Combination of in silico Screening Studies, Synthesis, and Biological Activity Evaluation-Reference-Cited by-同舟云学术

A Diarylpentanoid with Potential Activation of the p53 Pathway: Combination of in silico Screening Studies, Synthesis, and Biological Activity Evaluation

Published:2021-07-22 Issue:19 Volume:16 Page:2969-2981
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Moreira Joana¹²^ORCID,Almeida Joana³,Loureiro Joana B.³,Ramos Helena³,Palmeira Andreia¹²,Pinto Madalena M.¹²,Saraiva Lucília³,Cidade Honorina¹²

Affiliation:

1. Laboratório de Química Orgânica e Farmacêutica Departamento de Ciências Químicas Faculdade de Farmácia Universidade do Porto Rua de Jorge Viterbo Ferreira, 228 4050-313 Porto Portugal

2. CIIMAR – Centro Interdisciplinar de Investigação Marinha e Ambiental Terminal de Cruzeiros do Porto de Leixões 4450-208 Matosinhos Portugal

3. LAQV/REQUIMTE Laboratório de Microbiologia Departamento de Ciências Biológicas Faculdade de Farmácia Universidade do Porto Rua de Jorge Viterbo Ferreira, 228 4050-313 Porto Portugal

Funder

European Regional Development Fund

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.202100337

Reference51 articles.

2. Regulation ofp53downstream genes

3. Control of apoptosis by p53

5. Wild type p53 reactivation: From lab bench to clinic

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