Suppression of 2,3,7,8-tetrachlorodibenzo- p -dioxin (TCDD)-mediated CYP1A1 and CYP1B1 induction by 12- O -tetradecanoylphorbol-13-acetate: role of transforming growth factor β and mitogen-activated protein kinases 1 1Abbreviations: AHR, aryl hydrocarbon receptor; ALDH4, aldehyde dehydrogenase class 4; ARNT, aryl hydrocarbon receptor nuclear translocator; CYP, cytochrome P450; DRE, dioxin response element; ERKs, extracellular signal-regulated kinases; MAPK, mitogen-activated protein kinase; MEK, MAPK kinase; NQO1, NADP(H):quinone oxidoreductase; PKC, protein kinase C; TCDD, 2,3,7,8-tetrachlorodibenzo-p-dioxin; TGFβ, transforming growth factor β; and TPA, 12-O-tetradecanoylphorbol-13-acetate.-Reference-Cited by-同舟云学术

Suppression of 2,3,7,8-tetrachlorodibenzo- p -dioxin (TCDD)-mediated CYP1A1 and CYP1B1 induction by 12- O -tetradecanoylphorbol-13-acetate: role of transforming growth factor β and mitogen-activated protein kinases 1 1Abbreviations: AHR, aryl hydrocarbon receptor; ALDH4, aldehyde dehydrogenase class 4; ARNT, aryl hydrocarbon receptor nuclear translocator; CYP, cytochrome P450; DRE, dioxin response element; ERKs, extracellular signal-regulated kinases; MAPK, mitogen-activated protein kinase; MEK, MAPK kinase; NQO1, NADP(H):quinone oxidoreductase; PKC, protein kinase C; TCDD, 2,3,7,8-tetrachlorodibenzo-p-dioxin; TGFβ, transforming growth factor β; and TPA, 12-O-tetradecanoylphorbol-13-acetate.

Published:2001-12 Issue:11 Volume:62 Page:1449-1457
ISSN:0006-2952
Container-title:Biochemical Pharmacology
language:en
Short-container-title:Biochemical Pharmacology

Author:

Guo Meng,Joiakim Aby,Dudley David T.,Reiners John J.

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference48 articles.

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5. Transforming growth factor-β1 inhibits TCDD-induced cytochrome P4501A1 expression in human lung cancer A549 cells;Vogel;Arch Toxicol,1994

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