Inhibitory effect of YC-1 on the hypoxic induction of erythropoietin and vascular endothelial growth factor in Hep3B cells11Abbreviations: EPO, erythropoietin; VEGF, vascular endothelial growth factor; HIF, hypoxia-inducible factor; NO, nitric oxide; NOS, nitric oxide synthase; CO, carbon monoxide; sGC, soluble guanylate cyclase; cGMP, cyclic GMP; YC-1, 3-(5′-hydroxymethyl-2′-furyl)-1-benzylindazole; SNP, sodium nitroprusside; ODQ, 1H-(1,2,4)oxadiazole (4,3a)quinoxatin-1-one; MB, methylene blue; NAME, N(G)-nitro-L-arginine methyl ester; RT-PCR, reverse transcription polymerase chain reaction; and EMSA, electrophoretic mobility gel shift.-Reference-Cited by-同舟云学术

Inhibitory effect of YC-1 on the hypoxic induction of erythropoietin and vascular endothelial growth factor in Hep3B cells11Abbreviations: EPO, erythropoietin; VEGF, vascular endothelial growth factor; HIF, hypoxia-inducible factor; NO, nitric oxide; NOS, nitric oxide synthase; CO, carbon monoxide; sGC, soluble guanylate cyclase; cGMP, cyclic GMP; YC-1, 3-(5′-hydroxymethyl-2′-furyl)-1-benzylindazole; SNP, sodium nitroprusside; ODQ, 1H-(1,2,4)oxadiazole (4,3a)quinoxatin-1-one; MB, methylene blue; NAME, N(G)-nitro-L-arginine methyl ester; RT-PCR, reverse transcription polymerase chain reaction; and EMSA, electrophoretic mobility gel shift.

Published:2001-04 Issue:8 Volume:61 Page:947-954
ISSN:0006-2952
Container-title:Biochemical Pharmacology
language:en
Short-container-title:Biochemical Pharmacology

Author:

Chun Yang-Sook,Yeo Eun-Jin,Choi Eunjoo,Teng Che-Ming,Bae Jae-Moon,Kim Myung-Suk,Park Jong-Wan

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference26 articles.

1. Oxygen sensing, hypoxia-inducible factor-1 and the regulation of mammalian gene expression;Ratcliffe;J Exp Biol,1998

2. Oxygen(es) and the hypoxia-inducible factor-1;Wenger;Biol Chem,1997

3. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension;Wang;Proc Natl Acad Sci USA,1995

4. Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit;Huang;J Biol Chem,1996

5. Regulation of hypoxia-inducible factor 1 alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway;Huang;Proc Natl Acad Sci USA,1998

Cited by 144 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. HIF-1 inhibition reverses opacity in a rat model of galactose-induced cataract;PLOS ONE;2024-02-28

2. Modulation of hypoxia-inducible factor-1 signaling pathways in cancer angiogenesis, invasion, and metastasis by natural compounds: a comprehensive and critical review;Cancer and Metastasis Reviews;2023-10-04

3. Hypoxia-inducible factor 1α/IL-6 axis in activated hepatic stellate cells aggravates liver fibrosis;Biochemical and Biophysical Research Communications;2023-04

4. Thiamine insufficiency induces Hypoxia Inducible Factor-1α as an upstream mediator for neurotoxicity and AD-like pathology;Molecular and Cellular Neuroscience;2022-12

5. Targeting HIF-1α by Natural and Synthetic Compounds: A Promising Approach for Anti-Cancer Therapeutics Development;Molecules;2022-08-15