Down-regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase mRNA levels and synthesis in Syrian hamster C100 cells by the oxidosqualene cyclase inhibitor [4′-(6-allyl-ethyl-amino-hexyloxy)-2′-fluoro-phenyl]-(4-bromophenyl)-methanone (Ro 48–8071): comparison to simvastatin-Reference-Cited by-同舟云学术

Down-regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase mRNA levels and synthesis in Syrian hamster C100 cells by the oxidosqualene cyclase inhibitor [4′-(6-allyl-ethyl-amino-hexyloxy)-2′-fluoro-phenyl]-(4-bromophenyl)-methanone (Ro 48–8071): comparison to simvastatin

Published:1998-08 Issue:4 Volume:56 Page:439-449
ISSN:0006-2952
Container-title:Biochemical Pharmacology
language:en
Short-container-title:Biochemical Pharmacology

Author:

Peffley Dennis M.,Gayen Apurba K.,Morand Olivier H.

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference53 articles.

1. Morand OH, Aebi J, Dehmlow H, Ji YH, Gains N, Lengsfeld H and Himber J, Ro 48–8071, a new 2,3-oxidosqualene cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys and minipigs; comparison to simvastatin. J Lipid Res38: 148–114, 1997.

2. Effects of a novel 2,3-oxidosqualene cyclase inhibitor on the regulation of cholesterol biosynthesis in Hep-G2 cells;Mark;J Lipid Res,1996

3. Biosynthesis of 24,25-epoxycholesterol from squalene 2,3;22,23-dioxide;Nelson;J Biol Chem,1981

4. 24(S),25-Epoxycholesterol, evidence consistent with a role in the regulation of hepatic cholesterologenesis;Spencer;J Biol Chem,1985

5. 24,25-Epoxysterol metabolism in cultured mammalian cells and repression of 3-hydroxy-3-methylglutaryl-CoA reductase;Taylor;J Biol Chem,1986

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