Synthesis of (+)-dynemicin A and analogs of wide structural variability: establishment of the absolute configuration of natural dynemicin A

Author:

Myers Andrew G.,Fraley Mark E.,Tom Norma J.,Cohen Scott B.,Madar David J.

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,Molecular Medicine,General Medicine,Biochemistry

Reference29 articles.

1. Crystal and molecular structure of dynemicin A: a novel 1,5-diyn-3-ene antitumor antibiotic;Konishi;J. Am. Chem. Soc.,1990

2. Dynemicins, new antibiotics with the 1,5-diyn-3-ene and anthraquinone subunit. II. Antitumor activity of dynemicin A and its triacetyl derivative;Kamei;J. Antibiot. (Tokyo),1991

3. Chemistry and biology of the enediyne anticancer antibiotics;Nicolaou;Angew. Chem. Int. Ed. Engl.,1991

4. DNA intercalation and cleavage of an antitumor antibiotic dynemicin that contains anthracycline and enediyne cores;Sugiura,1990

5. Bioreductive alkylation as a trigger for toxic effects of dynemicin;Semmelhack;Tetrahedron Lett.,1990

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