Bioreductive alkylation as a trigger for toxic effects of dynemicin
Author:
Publisher
Elsevier BV
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Reference8 articles.
1. Dynemicin A, a novel antibiotic with the anthraquinone and 1,5-diyn-3-ene subunit.
2. The cyclization of calichemicin-esperamicin analogs: a predictive biradicaloid transition state
3. Experimental modeling of the priming mechanism of the calicheamicin/esperamicin antibiotics: actuation by the addition of intramolecular nucleophiles to the bridgehead double bond
4. Cyclic conjugated enediynes related to calicheamicins and esperamicins: calculations, synthesis, and properties
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