Hedamycin intercalates the DNA helix and, through carbohydrate-mediated recognition in the minor groove, directs N7-alkylation of guanine in the major groove in a sequence-specific manner-Reference-Cited by-同舟云学术

Hedamycin intercalates the DNA helix and, through carbohydrate-mediated recognition in the minor groove, directs N7-alkylation of guanine in the major groove in a sequence-specific manner

Published:1995-04 Issue:4 Volume:2 Page:229-240
ISSN:1074-5521
Container-title:Chemistry & Biology
language:en
Short-container-title:Chemistry & Biology

Author:

Hansen Mark,Yun Sang,Hurley Laurence

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,Molecular Medicine,General Medicine,Biochemistry

Reference44 articles.

1. Structure of the altromycin B (N7-guanine) adduct. A proposed prototypic DNA adduct structure for the pluramycin antitumor antibiotics;Sun;Biochemistry,1993

2. Altromycin B threads the DNA helix interacting with both the major and the minor grooves to position itself for site-directed alkylation of guanine N7;Hansen;J. Am. Chem. Soc.,1995

3. Sapurimycin, new antitumor antibiotic produced by Streptomyces;Uosaki;J. Antibiot. (Tokyo),1991

4. Structure and properties of major largomycin FII chromophore components;Gonda;J. ntibiot. (Tokyo),1984

5. Structures of the novel anthraquinone antitumor antibiotics, DC92-B and DC92-D;Yasuzawa;J. Antibiot. (Tokyo),1990

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