Synthesis and β-lactamase-mediated activation of a cephalosporin-taxol prodrug

Author:

Rodrigues Maria L.,Carter Paul,Wirth Cindy,Mullins Sheldon,Lee Arthur,Blackburn Brent K.

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,Molecular Medicine,General Medicine,Biochemistry

Reference29 articles.

1. Generation of cytotoxic agents targeted by enzymes;Senter;Bioconjugate Chem.,1993

2. Antibody-directed enzyme prodrug therapy;Bagshawe;Clin. Pharmacokinet.,1994

3. Site-specific prodrug activation by antibody-β-lactamase conjugates: regression and longterm growth inhibition of human colon carcinoma xenograft models;Meyer;Cancer Res.,1993

4. Tumor-selective prodrug activation by fusion protein-mediated catalysis;Bosslet;Cancer Res.,1994

5. Regression of established breast carcinoma xenografts with antibody-directed enzyme prodrug therapy against c-erbB2 p185;Eccles;Cancer Res.,1994

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