Exploitation of Antibiotic Resistance as a Novel Drug Target: Development of a β-Lactamase-Activated Antibacterial Prodrug-Reference-Cited by-同舟云学术

Exploitation of Antibiotic Resistance as a Novel Drug Target: Development of a β-Lactamase-Activated Antibacterial Prodrug

Published:2019-04-22 Issue:9 Volume:62 Page:4411-4425
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Evans Lindsay E.¹²^ORCID,Krishna Aishwarya¹,Ma Yajing²,Webb Thomas E.³,Marshall Dominic C.³,Tooke Catherine L.⁴,Spencer James⁴^ORCID,Clarke Thomas B.¹,Armstrong Alan²^ORCID,Edwards Andrew M.¹

Affiliation:

1. MRC Centre for Molecular Bacteriology and Infection, Imperial College London, SW7 2AZ London, United Kingdom

2. Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, W12 0BZ London, United Kingdom

3. Department of Medicine, Imperial College London, SW7 2AZ London, United Kingdom

4. School of Cellular and Molecular Medicine, University of Bristol, Biomedical Sciences Building, University Walk, BS8 1TD Bristol, United Kingdom

Funder

Biotechnology and Biological Sciences Research Council

Royal Society

Imperial College London

Engineering and Physical Sciences Research Council

National Institute for Health Research

Wellcome Trust

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b01923

Reference82 articles.

1. Update on the antibiotic resistance crisis

2. Beta-lactam antibiotics: from antibiosis to resistance and bacteriology

3. β-Lactams

4. Proliferation and significance of clinically relevant β-lactamases

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