Exploitation of Antibiotic Resistance as a Novel Drug Target: Development of a β-Lactamase-Activated Antibacterial Prodrug

Author:

Evans Lindsay E.12ORCID,Krishna Aishwarya1,Ma Yajing2,Webb Thomas E.3,Marshall Dominic C.3,Tooke Catherine L.4,Spencer James4ORCID,Clarke Thomas B.1,Armstrong Alan2ORCID,Edwards Andrew M.1

Affiliation:

1. MRC Centre for Molecular Bacteriology and Infection, Imperial College London, SW7 2AZ London, United Kingdom

2. Department of Chemistry, Molecular Sciences Research Hub, Imperial College London, W12 0BZ London, United Kingdom

3. Department of Medicine, Imperial College London, SW7 2AZ London, United Kingdom

4. School of Cellular and Molecular Medicine, University of Bristol, Biomedical Sciences Building, University Walk, BS8 1TD Bristol, United Kingdom

Funder

Biotechnology and Biological Sciences Research Council

Royal Society

Imperial College London

Engineering and Physical Sciences Research Council

National Institute for Health Research

Wellcome Trust

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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