Association between faecal shedding of feline coronavirus and serum α1-acid glycoprotein sialylation

Author:

Paltrinieri Saverio1,Gelain Maria E.1,Ceciliani Fabrizio1,Ribera Alba M.1,Battilani Mara2

Affiliation:

1. Dipartimento di Patologia Animale Igiene e Sanità Pubblica Veterinaria, Via Celoria 10, 20133 Milan, Italy

2. Dipartimento di Sanità Pubblica Veterinaria e Patologia Animale, Alma Mater Studiorum-Università di Bologna, Via Tolara di Sopra, 50, 40064 Ozzano dell'Emilia, Italy

Abstract

The sialylation pattern of serum α1-acid glycoprotein (AGP) in non-symptomatic cats infected by feline coronavirus (FCoV) and its possible relationship with the amount of FCoVs shed in faeces were investigated. Blood from three specific pathogen-free cats (group A) and from 10 non-symptomatic FCoV-positive cats from catteries with low (group B, three cats) or high (group C, seven cats) levels of faecal shedding were collected monthly. AGP was purified from serum and Western blotting followed by lectin-staining of α(2,3)-linked and α(2,6)-linked sialic acid. Faecal shedding was quantified in group C by quantitative polymerase chain reaction. Variations of AGP sialylation were recorded only in cats from group C, on which viral shedding peaked before the occurrence of feline infectious peritonitis (FIP) in the cattery, and decreased 1 month later, when serum AGP had an increase of α(2,3)-linked sialic acid. These results suggest that hypersialylation of AGP may be involved in host–virus interactions.

Publisher

SAGE Publications

Subject

Small Animals

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