Fused pyrazine mono-n-oxides as bioreductive drugs. II cytotoxicity in human cells and oncogenicity in a rodent transformation assay

Author:

Langmuir Virginia K.,Laderoute Keith R.,Mendonca Holly L.,Sutherland Robert M.,Hei Tom K.,Liu Su-Xian,Hall Eric J.,Naylor Matthew A.,Adams Gerald E.

Publisher

Elsevier BV

Subject

Cancer Research,Radiology, Nuclear Medicine and imaging,Oncology,Radiation

Reference19 articles.

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2. Sensitizers and protectors in radiotherapy;Brown;Cancer,1985

3. Potentiation by the hypoxic cytotoxin SR 4233 of cell killing produced by fractionated irradiation of mouse tumors;Brown;Cancer Res.,1990

4. Oral (po) dosing with RSU 1069 or RB 6145 maintains their potency as hypoxic cell radiosensitizers and cytotoxins but reduces systemic toxicity compared with parenteral (ip) administration in mice;Cole;Int. J. Radiat. Oncol. Biol. Phys.,1991

5. Secondary neoplasms in patients treated for cancer: Etiology and perspective;Coleman;Radiat. Res.,1982

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