Inhibitors of thymidylate synthase and dihydrofolate reductase potentiate the antiviral effect of acyclovir

Author:

Prichard Mark N.,Prichard Lynn E.,Shipman Charles

Publisher

Elsevier BV

Subject

Virology,Pharmacology

Reference27 articles.

1. Thymidylate synthase is the principal target enzyme for the cytostatic activity of (E)-5-(2-bromovinyl)-2′-deoxyuridine against murine mammary carcinoma (FM3A) cells transformed with the herpes simplex virus type 1 or type 2 thymidine kinase gene;Balzarini;Mol. Pharmacol.,1987

2. Deoxyribonucleotide metabolism in herpes simplex virus infected HeLa cells;Cheng;Biochim. Biophys. Acta,1975

3. Deoxythymidine kinase induced in HeLa TK− cells by herpes simplex virus type 1 and type 2;Cheng;J. Biol. Chem.,1976

4. Roles of thymidylate synthetase activity in herpes simplex virus-infected HeLa cells;Cheng;Biochem. Pharmacol.,1978

5. 5-nitro-2′-deoxyuridine and 5-nitro-2′-deoxyuridine 5′-monophosphate: Antiviral activity and inhibition of thymidylate synthetase in vivo;De Clercq;Mol. Pharmacol.,1978

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